![]() ![]() More than 90% is excreted in the urine in one day in dogs and two days in cats, mainly as unchanged drug. The elimination Half-Life is 4 hours in dogs and 8 hours in cats. ![]() The maximum blood concentration is reached in 30 to 120 minutes in fasted dogs and cats. But delayed Tmax slightly in cats without affecting other pharmacokinetic parameters and without affecting efficacy. Food intake did not influence the absorption of nitenpyram in dogs. Pharmacokinetic Parameters:Īfter oral administration to cats or dogs, nitenpyram absorption is rapid and greater than 90 %. The efficacy against fleas is 95-100% within 6 hours after administration and 100% within 24 hours without residual activity. So, this coincides with the first blood meal of the fleas, while it reaches the effective blood concentration of the drug. The effect on fleas is visible within 15 to 30 minutes after administration to the host animal. Nitenpyram did not inhibit acetylcholinesterase. He interrupts nerve conduction in the adult chip, causing his death. It binds nicotinic-type cholinergic receptors specific to insects by inhibiting them. Nitenpyram, the active substance, belongs to the class of neonicotinoids. The Nytempyran molecule in Capstar kills the fleas by interfering with the transmission of their neurological impulses. In order to better understand what is Capstar, we should look at its mode of action. There are no known contraindications to Capstar administration.Ĭapstar has been shown to kill > 98% of adult fleas living on the animal within 6 hours and 100% of these are eliminated 24 hours after a single administration. It is safe for adult cats and dogs as well as for those growing or at least 4 weeks of age, pregnant and lactating females, breeding females and male pets. It is used to rapidly kill the adult fleas living on cats, dogs, kittens and puppies that are at least 4 weeks old.Ĭapstar is anti-flea product in the form of an oral tablet that rapidly kills all adult fleas living on the animals after they have taken a blood meal. Capstar Use In Case Of Pregnancy And Lactation:.Overdose (Symptoms, Emergency Procedures, Antidotes):. ![]()
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